Undertaking a variety of benchmarking, audit, service evaluation and research which directly improve clinical outcomes is a core focus of RADiANT. As such, we have focused on the development of a portfolio of projects which aim to benefit patients and their family carers.
Current Research Projects
We currently support a number of grant funded primary research protocols which are listed below.
Title: Eye movement desensitisation and reprocessing for symptoms of post-traumatic stress disorder in adults with intellectual disabilities (Trauma-AID)
Investigators: Prof Paul Willner, Prof Philippa (Pippa) Anderson, Dr Bernadette Sewell, Dr Biza Stenfert Kroese, Dr Clair Clifford, Dr Derek Farrell, Dr Sara Willott, Mrs Vivien Cooper, Prof Alan Watkins, Prof Glynis Murphy, Prof Hayley Hutchings, Prof John Rose, Prof Jonathan Bisson, Prof Peter Langdon
Funder: National Institute of Health Research Health Technology Assessment Award: £1,319,412.48
Title: A multicentre double-blind placebo-controlled randomised trial of SerTRaline for AnxieTy in adults with Autism (STRATA)
Investigators: Dr Dheeraj Rai, Prof Helen Leonard, Dr Ailsa Russell, Dr Joanna Thorn, Dr Nicola Mills, Dr Raja Mukherjee, Dr Regi Alexander, Dr Stephanie MacNeill, Mr Jack Welch, Professor David Baldwin, Prof David Kessler, Prof Nicola Wiles, Prof Peter Langdon, Prof Traolach Brugha
Funder: National Institute of Health Research HTA (NIHR 127337), Award: £1,669,262.68 (+ AUD $557,029.40 by NHMRC Australia to Leonard H, Starkstein S & Glasson E for Perth centre), 2019- 2023.
Title: People with AuTism detained within hospitals: defining the population, understanding aetiology and improving Care patHways (The mATCH study).
Investigators: Prof Peter Langdon, Dr Regi Alexander, Prof Essi Viding, Prof Connor Duggan, Prof Lee Shepstone, Prof Sabyasachi Bhaumik, Dr John Devapriam, Dr Ekkehart Staufenberg, David Turner
Funder: National Institute of Health Research (NIHR) Research for Patient Benefit (RfPB) Programme: PB-PG-0214-33040, Award: £350,000, 2015- 2018.
Title: Spectrum 10K Study
Investigators: Prof Simon Baron-Cohen, Prof David Rowitch, Dr Matthew Hurles, Prof Daniel Geschwind
Funder: National Institute of Health Research (NIHR)
Title: RCT of group CBT for men with intellectual and/or developmental disabilities and harmful sexual behaviour (HaSB-IDD)
Investigators: Prof Glynis Murphy, Prof John Rose, Prof John Taylor, Mr Andy Inett, Dr Lee Shepstone, Mr David Turner, Dr Regi Alexander, Mrs Vivien Cooper and Prof Peter Langdon
Funder: National Institute for Health Research - Health Technology Assessment, Award: £1,544,377.06
Title: Brain in Hand
Chief Investigator: Dr Rohit Shankar
Co-Investigators:
Funder: Small Business Research Initiative (SBRI) award
Title: The Prevalence of Social Communication PRoblems in Adult Psychiatric INpaTients (The SPRINT study)
Chief Investigator: Dr Sam Tromans
Co-Investigators: Prof Terry Brugha, Prof Regi Alexander
Funder: NIHR Senior Investigator award
Title: Social informational processing and offenders with autism spectrum disorder.
Chief Investigator: Verity Chester
Co-Investigators: Prof Peter Langdon, Prof Karen Bunning, Prof Regi Alexander.
Funder: N/A
Title: The Experience of Sepsis amongst People with Learning Disabilities
Chief Investigator: Anne Hunt
Co-Investigators: Dr Julia Jones, Dr Kate Young
Funder: N/A
Investigators: Prof Paul Willner, Prof Philippa (Pippa) Anderson, Dr Bernadette Sewell, Dr Biza Stenfert Kroese, Dr Clair Clifford, Dr Derek Farrell, Dr Sara Willott, Mrs Vivien Cooper, Prof Alan Watkins, Prof Glynis Murphy, Prof Hayley Hutchings, Prof John Rose, Prof Jonathan Bisson, Prof Peter Langdon
Funder: National Institute of Health Research Health Technology Assessment Award: £1,319,412.48
Title: A multicentre double-blind placebo-controlled randomised trial of SerTRaline for AnxieTy in adults with Autism (STRATA)
Investigators: Dr Dheeraj Rai, Prof Helen Leonard, Dr Ailsa Russell, Dr Joanna Thorn, Dr Nicola Mills, Dr Raja Mukherjee, Dr Regi Alexander, Dr Stephanie MacNeill, Mr Jack Welch, Professor David Baldwin, Prof David Kessler, Prof Nicola Wiles, Prof Peter Langdon, Prof Traolach Brugha
Funder: National Institute of Health Research HTA (NIHR 127337), Award: £1,669,262.68 (+ AUD $557,029.40 by NHMRC Australia to Leonard H, Starkstein S & Glasson E for Perth centre), 2019- 2023.
Title: People with AuTism detained within hospitals: defining the population, understanding aetiology and improving Care patHways (The mATCH study).
Investigators: Prof Peter Langdon, Dr Regi Alexander, Prof Essi Viding, Prof Connor Duggan, Prof Lee Shepstone, Prof Sabyasachi Bhaumik, Dr John Devapriam, Dr Ekkehart Staufenberg, David Turner
Funder: National Institute of Health Research (NIHR) Research for Patient Benefit (RfPB) Programme: PB-PG-0214-33040, Award: £350,000, 2015- 2018.
Title: Spectrum 10K Study
Investigators: Prof Simon Baron-Cohen, Prof David Rowitch, Dr Matthew Hurles, Prof Daniel Geschwind
Funder: National Institute of Health Research (NIHR)
Title: RCT of group CBT for men with intellectual and/or developmental disabilities and harmful sexual behaviour (HaSB-IDD)
Investigators: Prof Glynis Murphy, Prof John Rose, Prof John Taylor, Mr Andy Inett, Dr Lee Shepstone, Mr David Turner, Dr Regi Alexander, Mrs Vivien Cooper and Prof Peter Langdon
Funder: National Institute for Health Research - Health Technology Assessment, Award: £1,544,377.06
Title: Brain in Hand
Chief Investigator: Dr Rohit Shankar
Co-Investigators:
Funder: Small Business Research Initiative (SBRI) award
Title: The Prevalence of Social Communication PRoblems in Adult Psychiatric INpaTients (The SPRINT study)
Chief Investigator: Dr Sam Tromans
Co-Investigators: Prof Terry Brugha, Prof Regi Alexander
Funder: NIHR Senior Investigator award
Title: Social informational processing and offenders with autism spectrum disorder.
Chief Investigator: Verity Chester
Co-Investigators: Prof Peter Langdon, Prof Karen Bunning, Prof Regi Alexander.
Funder: N/A
Title: The Experience of Sepsis amongst People with Learning Disabilities
Chief Investigator: Anne Hunt
Co-Investigators: Dr Julia Jones, Dr Kate Young
Funder: N/A
Benchmarking and Service Evaluation
The benchmarking and service evaluation projects on our portfolio aim to assess the standards of care offered to patients with neurodevelopmental disorders.
Patient and Carer Rated Outcome and Experience Measures in Intellectual Disability Services - The NHS Five Year Forward View (NHS England, 2014) emphasises outcome measurement within the three domains of effectiveness, safety and patient experience, to include the perspective of patients and their family carers. However, the feasibility of administering commonly used outcome measures to patients with intellectual disabilities had not been explored. The project follows on from a quality improvement (QI) project which evaluated the clinical utility of currently available outcome and experience measures for patients with intellectual disabilities and their family / carers. This QI project identified a number of issues with currently available measures, such as their inaccessibility to those with intellectual disabilities, or including domains not relevant to those with intellectual disabilities or their family carers. The current project therefore evaluates a number of adapted outcome and experience measures for this population, and is the first step towards benchmarking the perceptions of patients and their family carers on outcomes and experience
Avoiding Inappropriate Admission to Inpatient Care: An Evaluation of the Community based Enhanced Assessment and Treatment Service for People with Intellectual Disability, Autism, and Mental Health Problems (Alexander et al)
Pathways and outcomes of children and adolescents with ADHD referred to a CAMHS-LD team (Kiran, K., Weeks, C., Chester, V., & Alexander, R.T.)
Avoiding Inappropriate Admission to Inpatient Care: An Evaluation of the Community based Enhanced Assessment and Treatment Service for People with Intellectual Disability, Autism, and Mental Health Problems (Alexander et al)
Pathways and outcomes of children and adolescents with ADHD referred to a CAMHS-LD team (Kiran, K., Weeks, C., Chester, V., & Alexander, R.T.)